Inflammaging: Chronic Low-Grade Inflammation and Health

“To find health should be the object of the doctor.  Anyone can find disease.” (Andrew Taylor Still in Philosophy of Osteopathy).

A state of chronic, low-grade inflammation appears to develop within tissues and progressively worsen with age in most individuals.  Understanding this process and the factors that moderate it represent a major goal in maintaining good health. 

In this two-day seminar we will examine the impact of chronic, low-grade inflammation on multiple organ systems and, ultimately, on the health of the individual. 

In conclusion we will look at the effects of physical activity on modifying the metabolic structure of the individual and its role suppression of inflammaging and restoration of health.

Programme

Acute verse chronic inflammatory processes

• Massive systemic Inflammation and its consequences
• Low-grade systemic inflammation and its consequences

The origins of low-grade systemic inflammation – risk factors

• The Exposome – summation of exposure to environmental factors

Long-term consequences of chronic systemic inflammation – Cell Signaling and Transduction Pathways

• Inflammaging at a cellular level – Senescence-Associated Secretory Phenotype
• Accumulation of cellular debris with aging: “Garb-aging”
• Inflammaging – impact on the immune system
• Inflammaging and the gut microbiota
• Inflammaging and the cardiovascular system
• Inflammaging and the musculoskeletal system
• Inflammaging and the nervous system

Pharmaceutically modifying cellular signaling and transduction pathways and the problem with the concept of a “Magic Bullet” for treating inflammaging

Metabolomics and the role of physical activity in the treatment of inflammaging

“The Diseasome” of physical inactivity

• The burden of inflammation on health – tipping the balance

The approach to treatment: Medicine finally arrives at the Osteopathic Concept

• The five models of Osteopathuc Philosophy and their impact on inflammaging – re-establishing the balance.